Signed informed consent must be obtained prior to participation in the study. * Dose escalation and dose expansion group 1: Patients with histologically or cytologically confirmed diagnosis of ...

你知道吗？在世界之巅——珠穆朗玛峰，人类的身体会发生惊人的变化。2025年1月1日，华大生命科学研究院主导的'珠峰行动计划'研究成果在《细胞报告》发表，首次揭示了高海拔环境下人体免疫系统和代谢的动态变化。这项研究不仅让我们对极限环境下的生理适应有了更深的理解，更为未来健康研究提供了重要线索。

Autoimmune diseases are a pathophysiological state wherein immune responses are directed against, and damage, the body's own tissues (autoimmunity). Common examples of autoimmune disease include ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The oncogenic mechanisms by which TFE3 fusion ...

The incidence of hepatocellular carcinoma (HCC) is increasing worldwide. Extracellular vesicles (EVs) contain sufficient bioactive substances and are carriers of intercellular information exchange, as ...

利用实时定量逆转录聚合酶链反应（RT-qPCR）测定细胞色素 P450 家族 1 亚家族 A 成员 2（CYP1A2）、细胞色素 P450 家族 2 亚家族 E 成员 1（CYP2E1）、核因子红细胞 2 相关因子 2（NFE2L2）和 Kelch 样 ECH 相关蛋白 1（KEAP1）基因的 mRNA 水平。所有参数均在肝脏样本中进行分析。

Lung cancer, the leading cause of cancer-related deaths worldwide, can be classified into small cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC is the most common histological type, ...

微胶质细胞特异性抑制 GCase 活性会降低神经元中核因子红细胞 2 相关因子 2（NFE2L2）活性，使神经元易受氧化应激影响。PD 患者 PBMCs 中，携带 GBA1 和 SNCA A53T 突变的患者 GCase 蛋白表达显著降低，而 LRRK2 PD 患者 PBMCs 的 GCase 酶活性增加，这表明 LRRK2 激酶活性对 ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with ...