Background: MYCN is an oncogenic transcription factor of the MYC family and plays an important role in the formation of tissues and organs during development before birth. Due to the difficulty in ...

研究人员为开展此项研究，主要运用了以下关键技术方法：从 TARGET 和 FerrDb 数据库获取数据，运用 R 语言软件进行差异分析，筛选出相关差异表达基因（DEGs）；通过单变量 COX 分析、Lasso 回归分析和多变量 COX 分析构建预后模型并计算风险评分；利用 CIBERSORT 分析高风险（HR）和低风险（LR）人群免疫细胞浸润（ICI）差异；采用细胞实验和实时荧光定量 ...

撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化-蛋白酶体系统快速降解，在MYCN扩增的NB细胞中，Aurora-A激酶与SCF-Fbxw7 ...

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Scientists at The Institute of Cancer Research in London have made significant strides in understanding why some cases of neuroblastoma—a pedia ...

New research has provided insight into the biological mechanisms that may contribute to poor outcomes in certain cases of ...

Neuroblastoma, an aggressive malignancy originating from neural crest cells, accounts for 15% of cancer-related deaths in children. Treatment strategies include systemic chemotherapy, radiation or ...

Neuroblastoma (NB) is one of the most common solid tumors in children. Glycosyltransferases (GTs) play a crucial role in tumor development and immune escape and have been used as prognostic biomarkers ...