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中国医学科学院联合南京高校:纳米疫苗为心血管疾病预防提供新策略
2. 疫苗递送机制:基于SPION的载体通过清道夫受体A(SR-A)和甘露糖受体(MR)介导的内吞作用,显著增强了抗原和佐剂对树突状细胞(DC)的摄取。分解的SP-D和SP-P在内溶酶体中定位,增强了抗原的交叉呈递,从而最大限度地激活DC,促进1型免疫反应。 3. 预防性 ...
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