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4 天
治疗性激活产生 IL-22 的天然淋巴细胞可增强宿主对艰难梭菌感染的防御
研究人员评估了 R848 处理对 C57BL/6 和 Il22?/? 小鼠上皮糖基化和连接基因表达的影响。结果发现,R848 处理 24 小时后,宿主糖基转移酶基因 Mgat4a、Mgat5 和 St6gal1 以及紧密连接蛋白 ZO-1(由 Tjp1 编码)的表达以 IL-22 依赖的方式降低,这表明 R848 介导的保护作用并非由 ...
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