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14 小时
《科学》(20241206出版)一周论文导读
为了设计能够特异性靶向中枢神经系统(CNS)的细胞,我们鉴定了细胞外中枢神经系统特异性抗原,包括中枢神经系统细胞外基质的成分和在神经元或胶质细胞上表达的表面分子。 用于检测这些抗原的合成Notch受体被用于编程改造T细胞,仅在大脑中诱导不同有效载荷的表达。诱导嵌合抗原受体表达的CNS靶向T细胞有效清除了原发性和继发性脑肿瘤,而不损害脑外交叉反应细胞。 此外,局部递送免疫抑制细胞因子白介素—10的中 ...
London South East
12 小时
Condor Gold Share Chat (CNR)
An extra 10p to 20p up-front - at least - surely is viable! A lot of people bashing Mark Childs on here. Please find some grace and step out of your matrix. Whilst I understand the frustration, I'm ...
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