童童的经历，是医院“永远以孩子为先”理念的生动诠释。未来，医院将继续探索儿童晚期肿瘤的精准姑息技术，让每一个生命都能得到爱与尊严。医学有界，仁爱无疆，让我们共同守护每一颗生命的星光。

8岁的童童（化名）因反复腹痛入院，检查结果令人揪心：他的结肠有肿块样增生，并伴随结肠狭窄，肿瘤已经在全身多发转移，腹腔存在积液。面对肿瘤终末期且无法手术的残酷现实，童童的家长只有一个朴素的愿望：‘让孩子减轻痛苦，改善肠道狭窄。’ ...

总的来说，这项研究是中国首次针对结直肠息肉病遗传谱的多中心临床研究。它不仅建立了中国结直肠息肉病数据库，还揭示了中国人群结直肠息肉病遗传变异谱的特征，发现与国外研究在 APC 突变率和突变类型上存在差异。研究结果为中国结直肠息肉病患者的临床诊断、治疗和遗传咨询提供了重要依据，也为进一步探索结直肠息肉病的发病机制奠定了基础，有助于推动精准肿瘤学在结直肠息肉病领域的发展。

Next-generation sequencing (NGS) detected multiple clinically significant variants, including MSH2, NF1, MTOR, PTEN, TSC2, ATRX, TP53, MUTYH and RB1. No pathogenic variants were seen in BRAF, IDH1, ...

Conditions such as Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis are known to elevate CRC risk by causing the development of numerous precancerous polyps or making ...

经典型家族性腺瘤性息肉病（Famili?re adenomat?se Polypose，FAP）从 12 - 14 岁开始，attenuierte 型（AFAP）和 MUTYH 相关息肉病（MUTYH-assoziierte Polypose，MAP）从 18 - 20 岁开始，每 1 - 2 年进行一次结肠镜检查；从 25 岁开始，每 1 - 5 年进行一次胃镜检查观察十二指肠乳头1415。

Introduction: Breast cancer continues to be a primary cause of cancer-related mortality among women globally. Identifying novel biomarkers is essential for enhancing patient prognosis and informing ...

Background and aims Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1–2 years. However, ...