来自日本的研究团队通过全国性回顾调查，揭示了儿童Rosai-Dorfman-Destombes病(RDD)的临床特征与分子机制。研究发现83.3%的患儿 ...

For example, cutaneous or mucosal CM is considered the somatic mutation of GNAQ/GNA11; common VM is caused by somatic mutation of TEK, whereas sporadic AVM results from MAP2K1 somatic mutation. Some ...

Beyond KRAS, patients with KRAS G12C-mutated colorectal cancers were most commonly characterized by alterations including both point mutations and amplifications of NRAS, BRAF, MAP2K1, and EGFR ...

Beyond KRAS, patients with KRAS G12C-mutated colorectal cancers were most commonly characterized by alterations including both point mutations and amplifications of NRAS, BRAF, MAP2K1, and EGFR ...

Beyond KRAS, patients with KRAS G12C-mutated colorectal cancers were most commonly characterized by alterations including both point mutations and amplifications of NRAS, BRAF, MAP2K1, and EGFR, ...

Get Instant Summarized Text (Gist) Genetic alterations co-occurring with the KRAS G12C mutation may contribute to primary resistance to KRAS G12C inhibitors in colorectal and pancreatic cancers ...

1Department of Oncology, Mayo Clinic, Rochester, Minnesota.

除了KRAS，携带KRAS G12C突变的结直肠癌患者最常见的改变包括NRAS、BRAF、MAP2K1和EGFR的点突变和扩增，而MYC扩增则存在于两个胰腺癌患者队列中携带KRAS G12C突变的肿瘤中。 最值得注意的是，胰腺癌患者的肿瘤中如果存在KRAS G12C和耐药相关共存突变（包括其他非G12C ...

Among patients with KRAS G12C mutations, candidate primary resistance mutations were detected in many patients with colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC), which may ...

School of Computer, Jiangsu University of Science and Technology, 666 Changhui Road, Zhenjiang 212100, China State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM) ...