DSPE提供脂质锚定功能，PEG链（分子量可选350-10000Da）确保水溶性和生物相容性，末端M6P作为靶向基团。 M6P受体（M6PR）在肝细胞、巨噬细胞及某些肿瘤细胞表面高表达。DSPE-PEG-M6P修饰的纳米粒通过M6PR介导的内吞途径进入细胞，溶酶体共定位效率较非靶向载体提升8 ...

FZU - Institute of Physics of the Czech Academy of Sciences, 182 21 Prague, Czech Republic Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 121 16 Prague 2, Czech Republic FZU - ...