m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated ...

Here, the authors propose that changes in m6A levels may be predictable via a simple model that is based exclusively on mRNA metabolic events. Under this model, m6A mRNAs are "passive" victims of RNA ...

胃癌，作为全球范围内发病率较高的恶性肿瘤之一，其发病机制一直是医学研究的热点。近年来，越来越多的研究表明，幽门螺杆菌感染与胃癌的发生密切相关。然而，关于幽门螺杆菌如何诱发胃癌，以及即使根除后为何仍有可能发生胃癌的问题，科学界尚未完全阐明。陆军军医大学 ...

废用性骨质疏松（DOP）因机械负荷不足导致骨形成受阻，现有疗法难以满足临床需求。中南大学湘雅医院团队发现circ-ITCH通过招募m 6 A阅读蛋白IGF2BP2稳定BRCA1 mRNA，促进HOXC10泛素化降解，从而逆转微重力环境下骨髓间充质干细胞（BM-MSCs）的成骨分化抑制。该研究 ...

In the MZT, METTL3 mediates the m6A modification on pre-mRNA to degrade maternal mRNA and YTHDF2 can promote the process, which is reprogramming zygotic mRNA for zygotic development. Finally, in the ...