Background: Colorectal cancer (CRC) is a malignant tumor of the digestive tract that significantly impacts human health. LDL receptor-related protein 1B (LRP1B) may play a crucial role in ...

编辑推荐：为解决结直肠癌(CRC)诊断和治疗策略不足的问题，捷克马萨里克大学团队通过RNA测序技术分析了五种常用CRC细胞系 ...

Department of Breast Surgery, The Affliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China Brain metastasis in breast cancer (BCBM) significantly threatens the survival and ...

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Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors Chondrosarcomas are rare cancers of cartilage with limited systemic therapy options. To ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

通过对肿瘤样本的基因测序，他们发现 TP53、MCL1、CCNE1 和 ZNF217 等基因的改变较为常见。其中，LRP1B 突变和 PI3K 通路改变与较差的无进展生存期（PFS）相关，意味着这两个因素可能会影响治疗效果。进一步研究发现，具有持久临床获益（DCB）的患者，其肿瘤组织 ...