Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion ...

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Integral membrane proteins such as receptors and ion channels span the membrane ... A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific ...

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