Liddle syndrome is an autosomal dominant disorder caused by hyperactivity of the amiloride-sensitive sodium channel (ENaC) of the principal cell of the cortical collecting tubule. In 1963 ...

Rod Liddle is associate editor of The Spectator. He writes a weekly column in the magazine, as well as contributing to The Sunday Times and The Sun. Je suis Andrew Gwynne ...

However, several promising HPA-modulating drugs have failed to reduce long-term cortisol in mood disorders, despite effectiveness in other hypercortisolism conditions such as Cushing’s syndrome. The ...