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miRNA 助力热放疗:开启局部晚期癌症治疗新征程
蛋白质免疫印迹分析表明,转染这 6 种 miRNA 模拟物后,SiHa 细胞中 HR 通路的关键蛋白 ATM 表达降低;在 NHEJ 通路方面,6 种 miRNA 均对 DNA 依赖蛋白激酶催化亚基(DNA - PKcs)的蛋白表达有显著影响,miR - 1293 强烈降低 Ku80 的蛋白表达,miR - 27a、miR - 221 和 miR - 224 ...
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