其中,β-羟基丁酸(BHB)作为酮体的主要成分之一,除了作为能量来源外,还被发现具有通过赖氨酸β-羟基丁酰化(Kbhb)修饰改善线粒体质量等多种生物学功能,但其是否以及如何调节MDVs的形成尚不清楚。 2025年3月20日,四川大学贾大教授团队在国际权威期刊 ...
近日,我院贾大教授团队在Molecular Cell发表了题为“β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions”的研究论文,该研究发现: β-羟基丁酸可以改善线粒体功能,Kbhb修饰在其中发挥着重要作用。
亮点: ?β- 羟基丁酸(BHB)通过赖氨酸 β- 羟基丁酰化(Kbhb)改善线粒体功能。 ?BHB 促进分选衔接蛋白 9(SNX9,线粒体衍生小泡(MDV)形成的调节因子)的 Kbhb。 ?SNX9 的 Kbhb 促进线粒体内膜 MDV 的生成。 ?SNX9 的 Kbhb 保护小鼠免受酒精诱导的肝损伤。 摘要 ...
The Netherlands and Belgium are enthusiastically moving forward with the organisation of the FIH Hockey World Cup 2026 and ...
最近也有研究表明,BHB能诱导组蛋白和非组蛋白发生赖氨酸β-羟基丁酰化(lysine β-hydroxybutyrylation, Kbhb)。作为一种新型蛋白质翻译后修饰,Kbhb可以调节基因表达和细胞信号传导。然而,BHB以及BHB诱导的Kbhb修饰是否影响MDVs的生物发生,如何调控线粒体功能目前 ...
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She was brought to Khan Bahadur Haji Bachu (KBHB) Ali Eye Hospital in Patel, Mumbai where she was operated for both eyes free of cost. She has got her vision back. So what is so special about this ...
Congressman Dusty Johnson honored another group of Vietnam era veterans in Sturgis this week – and encountered some ...