Indeed, some but not all nucleoside analogs can inhibit telomerase activity 52. The results presented here indicate that specific, potent inhibitors of the hTERT enzyme are likely to be very ...

Rac1 activity could also be elevated by IL1β. Additionally, activated Rac1 promoted expression of MMP13, ADAMTS-5 and COLX by chondrocytes, partially through the β-catenin pathway. Moreover, ...

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

Discover how next-generation kinase inhibitors are transforming clinical therapy byovercoming resistance and enhancing ...

Furthermore, they have demonstrated that it is possible to reprogram other cancer cells to become dependent on this enzyme – ...

Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding ...

When a tumour develops, it creates a structure around itself called the tumour stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges.

Rasagiline demonstrates complete and selective inhibition of MAO-B and is at least ... and include upregulation of cellular antioxidant activity and antiapoptotic factors. Conclusion: Rasagiline ...

Ustiloxins are the main mycotoxin in rice false smut, a devastating disease caused by Ustilaginoidea virens. A typical phytotoxicity of ustiloxins is strong inhibition of seed germination, but the ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis ...