【导读】复发/转移性头颈部鳞状细胞癌(R/M-HNSCC)是一种严重且常致命的疾病。针对表皮生长因子受体(EGFR)的靶向治疗的临床疗效较低。
We have examined the expression profile of 11 AFI family members in the mouse bladder. INHA, INHBA, and follistatin are the major ligand subunits detected among the six examined in the bladder. ACVR1, ...
invGRN 确定了 INHBA、SNAI2、ITGB4 和 ITGA5 是 FaDu 和 Kyse30 侵袭细胞中共同诱导的调控枢纽。研究人员使用伏索利肽竞争性抑制 INHBA 同源二聚体基因产物 ...
In summary, the myCAF population serves not only as a prognostic indicator but also as a promising therapeutic target. Other myCAF markers, including INHBA, SULF1, CTHRC1, VCAN, and COL5A1, have also ...
aThe Cardiac Exercise Research Group at the Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway ...
研究结果令人振奋。首先,研究人员发现高剂量的表皮生长因子(EGF)能够促进肿瘤细胞的局部侵袭,而西妥昔单抗可以有效抑制这一过程。这表明 EGFR 在肿瘤侵袭过程中扮演着重要角色,为后续的研究指明了方向。进一步的研究发现,EGFR 介导的局部侵袭与上皮 - 间质转化(EMT)密切相关。通过基因集富集分析(GSEA),研究人员确定了 16 条在侵袭细胞中显著激活的标志性通路,其中 EMT ...
鼻咽癌是一种起源于鼻咽上皮的恶性肿瘤,因其位置隐蔽且早期症状不明显,大多数患者在就医时已发生淋巴结转移。复发和转移是导致鼻咽癌治疗效果不佳的主要原因。鼻咽癌的发生与发展涉及多种癌基因与肿瘤抑制基因的异常表达,但其具体发病机制尚未完全阐明。环状RNA(circular RNA, ...