Diabetic kidney disease (DKD) is a prevalent complication of diabetes mellitus (DM), and its incidence is increasing alongside the number of diabetes cases. Effective treatment and long-term ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

Juvenile dermatomyositis (JDM) is a rare autoimmune condition with insufficient biomarkers and treatments, in part, due to incomplete knowledge of the cell types mediating disease. We investigated ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

研究针对精神疾病相关问题，探究孕期感染和青春期应激对小鼠影响，发现二者协同影响小脑认知，有重要意义。 在神经科学与精神疾病研究领域，精神障碍如同神秘而棘手的谜题，严重干扰着人们的思维、情感和行为。大量研究表明，感染和社会挫败应激等 ...

在 HCC 中，虽然 MVI 对患者预后影响重大，但其遗传机制尚未完全明晰。目前已初步确定 ARID2、IGF2R、DENND5A、PIK3CA、IL6ST、ABCG2 等基因是 MVI 机制中的关键基因。生长因子、Wnt/β - catenin、RAS/RAF/MAPK 等信号通路，可能在 HCC 患者 MVI 的发生发展中发挥作用。此外 ...