IGFBP5 was identified as a key regulator of D-GAL induced senescence and fibrosis among fibroblasts using RNA-seq. And further validation tests showed that IGFBP5-knockdown could alleviate ...

The structural and functional integrity of glomerular cells is critical for maintaining normal kidney function. Glomerular diseases, which involve chronic histological damage to the kidney, are ...

如 C7 和 COLEC11 与纤维化进展有关，ALDOB 与 SAF 诊断正相关，IGF2、IGFALS、IGFBP3、IGFBP5 和 IGF1 等在肝纤维化进展中下调。此外，部分血浆蛋白质的变化无法由肝脏蛋白质组变化解释，却与脂肪组织蛋白质组变化相关，这凸显了多组织相互作用在 MASLD 中的重要性。