Liver TET1 was found to promote metabolic dysfunction-associated steatotic liver disease (MASLD) by regulating CD36 ...

A groundbreaking prognostic test developed through collaboration between The University of Western Australia and Perth-based ...

Researchers Identify Key Mechanism in Human Lung Development Oct. 31, 2024 — Researchers have shown that the IGFBP3 protein plays a relevant role in human lung development. The results of the ...

靶向敲低Alkbh5可逆转糖尿病小鼠的高血糖和高脂血症，显示出治疗代谢性疾病的潜力。 《Nature》杂志发表研究，揭示黄酮类化合物Naringenin（NAR）通过抑制IGFBP3表达，对椎间盘退行性病变（IDD）中的髓核细胞衰老和退化具有预防和治疗作用。研究利用生物信息学 ...

本文研究结果表明，IGFBP3/miR-34a 轴或能限制IGFBP3在胚胎未分化肺部上皮中的表达，处于假腺期的IGFBP3的逐渐下调或许是机体肺部肺泡分化所必需的。

四、生长激素治疗涉及哪些内容？本节提供了从儿童期开始的生长激素治疗的一些关键方面的问答。有关生长激素和治疗注意事项的更多信息可从附录C中列出的多个来源获得。01谁决定是否需要GH治疗？所有PWS患者都需要初级保健医生。然而，在决定儿童或成人是否可以使 ...

Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal ...

1 Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine ZMK, University of Bern, Bern, Switzerland 2 Laboratory for Oral Molecular Biology, Department of Orthodontics and ...

如 C7 和 COLEC11 与纤维化进展有关，ALDOB 与 SAF 诊断正相关，IGF2、IGFALS、IGFBP3、IGFBP5 和 IGF1 等在肝纤维化进展中下调。此外，部分血浆蛋白质的变化无法由肝脏蛋白质组变化解释，却与脂肪组织蛋白质组变化相关，这凸显了多组织相互作用在 MASLD 中的重要性。

Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics ...