本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

为探究 m6A 调节剂在肝癌（HCC）中的作用，研究人员发现 IGF2BP3 促进 HCC 进展，为其诊疗提供新方向。 肝癌（liver hepatocellular carcinoma，HCC）是一种常见且致命的肿瘤，中国的肝癌患者占全球病例的 50%。尽管近年来治疗手段有所进步，但疗效仍不理想。N6 - 甲基 ...

Using the XGBoost algorithm, we developed a classifier incorporating nine genes (ARHGAP9, CADM1, CPE, DUSP3, FGFR1, GALNT3, IGF2BP3, KIF26A, ZFP3). In our internal cohort, the classifier exhibited ...

1 The Second Clinical Medical College of Nanchang University, Nanchang, China 2 Department of Nephrology, Second Affiliated Hospital of Nanchang University, Nanchang, China This paper aims to ...

The RNA modification related enzymes may play opposite roles in different autoimmune diseases. RNA modification related enzymes exhibit distinct functions across various tissues and cells in ...

Following injury, many organs are capable of rapid regeneration of necrotic tissue to regain normal function. In contrast, the damaged heart typically replaces tissue with a collagen-rich scar, due to ...