Introduction: Cerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 ...

为探究 4 - 乙烯基环己烯二氧化物（VCD）对卵巢自噬的影响，研究发现其下调 IGF1R 引发过度自噬致卵巢早衰，意义重大。 研究人员主要运用了以下几种关键技术方法：通过构建小鼠模型，给 6 周龄的 C57BL/6 小鼠连续 15 天腹腔注射 VCD，模拟卵巢早衰情况；使用细胞培养技术培养人颗粒细胞样肿瘤细胞系 KGN 细胞，并对其进行 VCD 处理；采用转录组测序（RNA-Seq）分析 VCD ...

Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive cancer originating in the adrenal cortex, characterized by a high likelihood of recurrence and unfavorable survival rates, ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this study, the ...

Methods: To study accessibility and reproducibility in cardiovascular research reporting, we screened 639 randomly selected articles published in 2019 in three top cardiovascular science publications: ...

NT219 in combination with EGFR antibody cetuximab (Erbitux) is currently entering a Phase 2 study for head and neck cancer REHOVOT, Israel, March 05, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd.

NT219 in combination with EGFR antibody cetuximab (Erbitux) is currently entering a Phase 2 study for head and neck cancer ...

Malignant gliomas and medulloblastomas — the most common brain tumours affecting adults and children, respectively — remain responsible for a disproportionate level of morbidity and mortality ...

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在肿瘤治疗领域，KRAS基因的突变一直以来都是研究的重点，尤其是KRAS-G12C突变，它与多种癌症特别是肺癌、结直肠癌的发生密切相关。面对这种病症，为什么单一的靶向治疗效果不尽如人意？如何为患者提供更有效的治疗选择？这是许多科学家和治疗专家不断 ...