New therapeutic "cocktails" could offer long-lasting relief for treatment-resistant asthma and other inflammatory diseases of ...

其中，CTLA-4 和 PD-1 作为 B7/CD28 超家族的关键成员，已成为恶性肿瘤治疗的核心靶点。而 B7-H 家族作为免疫调节网络的重要组成部分，包括 B7-H2（ICOSL）、B7-H3、B7-H4、B7-H5（VISTA）、B7-H6 和 B7-H7（HHLA2）等成员，在肿瘤免疫调节中发挥着多样且关键的作用，为癌症 ...

Conversely, Tregs are also regulated by non-immune cells. Mesenchymal stem cells can activate Tregs through ICOS-ICOSL interactions, enabling Tregs to suppress the activity of ILC2s, which play a role ...

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and ...