总的来说,这项研究通过高内涵筛选技术发现了灵芝酸A作为一种前景广阔的抗衰老化合物,能够有效延缓细胞衰老并延长健康寿命。这一发现为抗衰老研究提供了全新的方向,并强调了天然产物在延缓衰老和提升健康水平方面的巨大潜力。
同时,HPV 的基因组整合状态、p16 INK4a 蛋白的表达,在宫颈癌的发展过程中到底扮演着怎样的角色,它们与 EBV 共感染以及病毒载量之间又有着怎样千丝万缕的联系,这些问题都亟待解决。为了给这些谜题找到答案,来自伊朗多所大学的研究人员展开了一项深入的 ...
为解决子宫内膜异位症现有药物治疗缺陷,名古屋大学研究人员开展关于细胞衰老与子宫内膜异位症关系及衰老疗法效果的研究。结果发现细胞衰老参与子宫内膜异位症发病机制,阿奇霉素(AZM)可抑制其进展。这为该病提供了潜在非激素治疗方案。
Malignant gliomas and medulloblastomas — the most common brain tumours affecting adults and children, respectively — remain responsible for a disproportionate level of morbidity and mortality ...
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant ...
In this valuable study, the authors aimed to identify and characterize intrinsic factors that govern the aging process of bone marrow mesenchymal stromal cells (BMSCs), which are believed to be ...
In PNAS, Nicaise et al. show cellular senescence targeting neural precursor cells (NPCs) as a potential mechanism to explain the lack of repair in patients with PPMS. MS brain tissue and uncovered a ...
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