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解析 BLOC-3 复合物冷冻电镜结构,解锁 Hermansky-Pudlak 综合征发病机制密码
为探究 BLOC-3 复合物结构、功能及与 Hermansky-Pudlak 综合征(HPS)关系,研究人员解析人 BLOC-3 复合物冷冻电镜结构,明确其与 RAB32/38、RAB9A 相互作用,发现相关突变影响复合物形成,为 HPS 诊断和治疗提供依据。 在生命的微观世界里,细胞内的各种 “小工厂 ...
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