【导读】反义环状 RNA 是一种特殊的环状 RNA，由亲本 mRNA 的反义互补链衍生而来。然而，反义环状 RNA 在肝细胞癌（HCC）中的功能仍不清楚。3月28日，中南大学湘雅医院研究团队在期刊《Cell ...

为探究肝癌（HCC）新治疗靶点和耐药机制，中南大学湘雅医院等研究人员开展了关于反义 circRNA（CSF3R-AS）的研究。结果发现 CSF3R-AS 可促进 HCC 进展和索拉非尼耐药，阻断相关正反馈回路有望提供新治疗靶点。

General transcription factor IIIC subunit 2 (GTF3C2) is one of the polymerase III transcription-related factors. Previous studies have revealed that ...

Department of Chemistry, College of Arts and Sciences, Washington State University, Pullman, Washington 99164, United States ...

Knockdown of GTF3C2 suppressed the proliferation of Hep3B and HCCLM3 cells, while overexpression of GTF3C2 facilitated the proliferation of SNU449 and Huh7 cells. GTF3C2 promoted USP21 expression ...

During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, ...

The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence ...

Hepatocellular carcinoma (HCC) represents the most prevalent form of liver cancer. Despite notable advancements in therapeutic strategies, HCC continues to pose significant public health challenges ...

1 Center for Cell and Gene Therapy, Center for Stem Cells and Regenerative Medicine, Baylor College of Medicine, Houston, Texas, USA 5 Texas Medical Center Digestive Diseases Center, Baylor College of ...