Researchers say findings suggest it may be possible to stop cancer growth using approaches such as restraining TE activity in ...
Scientists have long been curious about a mysterious part of our DNA called heterochromatin, often called the “dark side of ...
为探究 DNA 结合蛋白的可逆糖基化对转录的作用,研究人员开展 O-GlcNAc 相关研究,揭示其与 RNA Pol II 的相互作用,意义重大。 在生命科学的微观世界里,细胞的各项活动都受到精细的调控,其中转录过程更是像一场复杂而有序的交响乐,众多分子参与其中 ...
The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress ...
N-乙酰氨基葡萄糖(GlcNAc),系统命名为2-乙酰氨基-2-脱氧葡萄糖,是一种在医药、食品及化工领域等被广泛应用的重要多功能性单糖。GlcNAc 是自然界第二大天然多糖几丁质的基本组成单位,具有还原性。GlcNAc脱乙酰基后得到的氨基葡萄糖(GlcN)是人体细胞内 ...
结果显示,在肠道定植过程中,SC5314 中这些基因的表达水平显著高于部分临床分离株。此前研究表明,N - 乙酰葡糖胺(GlcNAc)是肠道中诱导白念珠菌菌丝相关转录的主要物质 。此次研究发现,临床分离株在 GlcNAc 刺激下,菌丝相关基因的表达明显低于 SC5314 ...
2 天on MSN
You may have heard of the fantastic-sounding "dark side of the genome." This poorly studied fraction of DNA, known as ...
How do cells keep transposable elements under control? Meet O-GlcNAc transferase (OGT), an enzyme at the heart of many essential cellular functions. According to the new study, OGT is also a lead ...
(iii) 用内切糖苷酶混合物C(Endo CC、Endo S 和 Endo H)处理样本,使用pFind分析糖苷酶混合物处理的质谱数据,分析带有“GlcNAc”或“GlcNAc-Fuc”修饰的产物,验证N-糖基化位点的鉴定结果。 在这项研究中,作者提出了一种基于综合质谱法从头解码蛋白质糖基化的方法 ...
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