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综述:活性氧(ROS)诱导的钙蛋白酶激活在癌症中的作用:机制 ...
同时,激活的钙蛋白酶还能够切割蛋白激酶 C(PKC),通过转化生长因子 -β1(TGF-β1)通路使蛋白激酶 B(AKT)发生磷酸化 ... 研究发现由钙蛋白酶活性产生的丝状肌动蛋白结合蛋白 A(filamin A)片段能够与 HIF - 1α 相互作用,促进其向细胞核的转运,进而促进 ...
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