Canine mast cell tumors (MCTs) are a significant concern in veterinary oncology, representing the most common malignant skin tumors in dogs. These tumors arise from mast cells, which are a type of ...

Recent research has focused on understanding the complex biology of mast cells, their interactions with other cells, and their roles in various diseases, including allergies, asthma, and cancer.

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling. Nature Cancer , 2025; DOI: 10.1038/s43018-024-00882-2 Cite This Page : ...

Breast cancer metastases are initiated by cancer cells that detach from the primary tumor and migrate to other organs via the bloodstream. These circulating cancer cells (CTCs) are extremely rare ...

Molecular Zip Code Draws Killer T Cells Straight to Brain Tumors Dec. 5, 2024 — Scientists have developed a 'molecular GPS' to guide immune cells into the brain and kill tumors without harming ...

The findings are published in Science Advances in an article titled, “Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells.” ...

This is a useful report of a spatially-extended model to study the complex interactions between immune cells, fibroblasts, and cancer cells, providing insights into how fibroblast activation can ...

More information: Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay., Cell (2024). DOI: 10.1016/j.cell.2024.07.014 Provided by Max Planck Institute of ...

The adoptive transfer of TCR-T cells specific to neoantigens preferentially exhibits potent cytotoxicity to tumor cells and has shown promising efficacy in various preclinical human cancers. In this ...

Ovarian cancer is caused by a harmful overgrowth of cells in and around the ovaries. The cancer can start in the lining of the ovary or fallopian tube, the supportive tissue, or in the egg cell. There ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...