*仅供医学专业人士阅读参考肽聚糖是细菌细胞壁的重要组成成分，其衍生物肽聚糖片段（PGFs），近年来被认为在维持肠道稳态中发挥了重要作用。但截至目前，PGFs与结直肠癌（CRC）之间的关系还不清楚。近期，南方医科大学珠江医院何肖龙/周宏伟/崔春晖团队与广州医科大学附属第二医院高杰团队联合发表了一项重要研究成果。他们 ...

In summary, we identified FRMD8 as a prognostic marker in breast cancer. FRMD8 regulates ERα level through a dual mechanism. Loss of FRMD8 inhibits ESR1 transcription via downregulating FOXO3A ...

Weaknesses: This manuscript repeatedly emphasizes the role of FRMD8/FOXO3A in tamoxifen resistance in ER-positive breast cancer, but the specific mechanisms have not yet been fully elucidated. Whether ...

AMHR2, anti-Müllerian hormone receptor 2; BMP15, bone morphogenic protein 15; BMPR2, bone morphogenetic protein receptor 2; FMR1, fragile X mental retardation; FSHR, follicle-stimulating hormone ...

科学依据：一项针对Wistar大鼠的实验显示，艾灸关元穴能显著提升肝脏组织中抗衰老蛋白SIRT1、FOXO3a的表达水平，同时降低炎症因子IL-1β、IL-6的含量7。 足三里位于膝盖外侧凹陷处下三寸（约四横指），是公认的"长寿穴"。日本有句俗语："若要安，三里常不干 ...

Rictor 基因缺失的细胞中，活性氧物质增多且 FOXO3a（叉头框蛋白 O3a）被激活，这显著改变了 β- 连环蛋白（β-catenin）与转录因子的功能性相互作用，使其从 TCF（T 细胞因子）转向 FOXO3a，进而强烈抑制经典的 Wnt/β-catenin 信号通路。研究结果强调了 Rictor 在协调 PI3K ...

当欧美抗衰市场仍沉迷于单一成分神话时，中国科学家已率先实现系统性基因抗衰突破。卓然长寿编码的「多靶点协同」「动态基因调控」理念，在《自然-衰老》等顶刊引发专题讨论。德国马普衰老研究所的Werner教授评价：「这标志着抗衰领域从『成分迷信』向『基因编程』的范式转变。」 ...

World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...