最近，体外和体内研究表明，暴露于扰动流的内皮细胞经历内皮-间充质转化（EndMT），这通过细胞间粘附的溶解、细胞极性的改变和间充质标志基因的表达来促进动脉粥样硬化的发展。与扰动流相反，单向层流抑制 EndMT。TGF-β（转化生长因子β）是驱动 EndMT 的 ...

图三：STAT3的表达受到EGF信号调控 4、探索OX40信号在内皮细胞中的下游信号转导及功能调控机制 接下来需要确定OX40是如何影响EC功能从而导致肿瘤恶化的，作者进行了转录组测序并对差异基因进行KEGG富集分析，发现其主要参与内皮-间质转化（EndMT）。检查scRNA-seq ...

为探究 MDA5 在皮肌炎（DM）血管损伤中的作用机制，研究发现 MDA5 蛋白介导的内质网应激 / 未折叠蛋白反应（UPR）促进血管内皮细胞向间充质细胞转化（EndMT），这与 MDA5 + DM 相关间质性肺病（ILD）有关。 皮肌炎（Dermatomyositis，DM）是一种特发性炎症性肌病 ...

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, ...

Hemodynamic shear stress, the frictional force exerted by blood flow on the endothelium, mediates vascular homeostasis. This review examines the biophysical nature and biochemical effects of shear ...

Background: Disulfiram (DSF) is an anti-alcoholic drug that has been reported to inhibit the epithelial-to-mesenchymal transition and crosslinking during fibrosis, pyroptosis, and inflammatory NF-κB ...