1Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

RALY acts as a key regulatory component in the Drosha complex, and promotes the post-transcriptional processing of a specific subset of miRNAs (miR-483, miR-676 and miR-877). These miRNAs ...

因此，在这项新研究中，研究团队探索了在人类 NK 细胞中利用 CRISPR-Cas9 基因编辑技术敲除 SMAD4 ，是否能够增强其对 TGFβ 的抗性，并通过利用 TGFβ 驱动的组织驻留特性来增强其抗肿瘤效力。

hLife由高福院士、董晨院士和Jules A.

6 Following transcription, the primary miRNA transcript is processed by the endoribonucleases Drosha/DGCR8 in the nucleus before transport into the cytoplasm. 7, 8 The resulting pre-miRNA is ...

Transcribed by RNA polymerase II as primary miRNAs (pri-miRNAs), miRNAs are processed in the nucleus by the Drosha-DGCR8 complex into precursor miRNAs (pre-miRNAs). Pre-miRNAs are then exported to the ...

MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally contributing to the development of different diseases including cancer. The miR-200 family consists of five ...

The manuscript provides valuable findings in the field for understanding the RNAi regulation in plants at the molecular level with a model of how DRB7.2 and DRB4 form a heterodimer and protect dsRNA ...

Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, ...

MSK-IMPACT胚系检测结果为阴性，体系检测显示微卫星不稳定-中间型（microsatellite instability-intermediate），并存在MLH1基因2-8号外显子缺失，以及ALOX12B、ARID1B、ASXL1、DCUN1D1、DROSHA、EP300、KEAP1、KMT2B、KMT2D和NPM1突变。免疫组化（IHC）证实MLH1及PMS2表达缺失。与SNP芯片分析 ...