In The New Mutants #98 (two issues before the series ended ... That said, he's smiling because he and Domino are threatening Deadpool with a variety of ways they'd like to send him packing.
Two issues into his run, he introduced Cable (played by Josh Brolin in Deadpool 2), and, shortly afterwards, Domino, Shatterstar, and Deadpool himself. It was an audacious debut that electrified ...