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腾讯网
8 天
浙江大学、苏州大学合作Nature论文,靶向液-液相分离,抑制肿瘤生长 ...
撰文丨王聪编辑丨王多鱼排版丨水成文最近的研究证据表明,细胞内通过液-液相分离(LLPS)形成的凝聚体,在人类健康和疾病中发挥着至关重要的作用。相分离的多分子复合物为细胞内生化反应的区室化提供了一种通用的调控机制。然而,哪些蛋白质在肿瘤细胞中发生液-液 ...
腾讯网
11 天
CRM:乳酸终于出卖了肿瘤!科学家发明新型给药系统,专打产生乳酸 ...
*仅供医学专业人士阅读参考肿瘤通过有氧糖酵解(瓦博格效应)产生的乳酸,简直是恶贯满盈。我们曾经介绍过,乳酸可以将瘤内的巨噬细胞从抗癌型变成促癌型[1-3],可以增强调节性T细胞的免疫抑制功能[4],还能把PD-1抑制剂变成促进免疫抑制的“毒药”[5] ...
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