More information: Yuanxin Yao et al, Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer, Frontiers of Medicine (2024).

After all, the cell must repeat its whole genetic material, including billions of genetic letters, before it can divide. Read ...

Our findings show where RNA editing takes place and which factors regulate it, allowing us to understand how RNA editing can ...

DNA stands for deoxyribonucleic acid. Nucleic acids are named for where they're found—inside the nuclei of cells—and for the ...

As Storici and other researchers continue probing RNA's effects in DNA repair, their revelations could have a lasting impact on human health and evolution. That means better gene therapies ...

By contrast, next-generation sequencing (NGS) for somatic genomic alterations is frequently performed across tumor types. We hypothesized that NGS would identify patients with alterations in mismatch ...

signaling the system to initiate gene silencing. "The 'R' in R-loop stands for RNA. All DNA-binding CRISPR-Cas systems use this structure to probe the DNA sequence and identify the correct target ...

Here the authors measure how the absence of certain DNA repair genes change the frequencies of unique mutational outcomes generated by Cas9 DSBs at synthetic target sequences in mouse embryonic ...

If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding ...

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, ...