肝细胞色素P7B1是BA合成途径中的限速酶，与NAFLD和糖尿病的进展和治疗密切相关。研究者还提出，通过激活CYP7B1驱动的替代BA合成途径来恢复BA生物合成的动态平衡状态，有利于许多代谢性疾病，包括肥胖、糖尿病、高胆固醇血症和NAFLD。在本研究中，我们发现 ...

动脉粥样硬化（atherosclerosis ，AS ）是一种脂质代谢失衡驱动的慢性炎症性疾病，可诱发多种外周动脉血管和心血管疾病（cardiovascular disease ，CVD ）。仅在2022 年，CVD 就导致全球约1 980 万人死亡，其中超过34% 的患者在70 岁之前死亡[1] 。AS 的危险因素复杂多样，不 ...

Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents.

11 IREC Imaging Platform, Université catholique de Louvain, Brussels, Belgium Correspondence to Professor Nathalie M Delzenne, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...