为解决镰状细胞病（SCD）患者骨健康受损且缺乏有效治疗手段的问题，研究人员开展了 FGF23 中和抗体（FGF23Ab）对 SCD 小鼠骨丢失影响的研究。结果显示 FGF23Ab 可部分改善 SCD 小鼠骨形成参数并提高血细胞比容，为 SCD 骨病治疗提供新方向。

We assessed the expression of bone remodeling markers (SOST, RANKL, OPG, CTsK), glycation markers (RAGE, AGER1), inflammatory cytokines (IL-6, TNF-α), and cellular functions, including proliferation, ...

We assessed the expression of bone remodeling markers (SOST, RANKL, OPG, CTsK), glycation markers (RAGE, AGER1), inflammatory cytokines (IL-6, TNF-α), and cellular functions, including proliferation, ...

特发性肺纤维化（idiopathic pulmonary fibrosis，IPF）是最常见的肺纤维化类型之一，以进行性呼吸困难直至呼吸衰竭为主要表现，因其病情不可逆，中位生存期不足5年[1]，常有“类肿瘤疾病”之称[2-3] ， 属中医“肺痹”“肺痿”等范畴。胃食管反流病（gastro-esophageal ...

Single cell RNA sequencing (scRNA-seq) can be used to resolve the cellular and molecular heterogeneity within a tissue by identifying cell populations with an unprecedented granularity along with ...

Colorectal liver metastasis (CRLM) represents a major therapeutic challenge in colorectal cancer (CRC), with complex interactions between the gut microbiota and the liver tumor microenvironment (TME) ...