However, the presence of nucleosomes and the folding of chromatin into 30-nanometer fibers pose barriers to the enzymes that unwind and copy DNA. It is therefore important for cells to have means ...

Although stem cell exhaustion is widely recognized as a hallmark of aging, our understanding of cell state changes–specifically, the dynamics of the transcriptome and open chromatin landscape, and ...

"The transposons behave differently during cell division and this can be used ... Telomemore enables single-cell analysis of cell cycle and chromatin condensation, Nucleic Acids Research (2025).

1Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 4Department of Urology, Shanghai ...

1 Laboratory of Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China 2 Endocrinology Division, Brigham and Women’s Hospital ... NONO is a DNA/RNA-binding protein, ...

In  a  paper  published  on  aBIOTECH,  the  authors  revealed  the  joint  regulation  of  chromatin structure and gene expression by BMI1s, the core components of Arabidopsis PRC1, and the condensin ...

Researchers say if their results are confirmed through further study they are optimistic the approach could be used to treat ...

Whether Sugp2 is a redundant gene for Sugp1 can be further verified by double-knockout experiments. In summary, our results showed that Sugp2 was a chromatin-associated protein and enriched in the ...

Researchers at Fred Hutch Cancer Center have discovered an overlooked mechanism driving aggressive breast and brain tumors ...

We defined SERBP1’s interactome, uncovered novel roles in splicing, cell division and ribosomal biogenesis, and showed its participation in pathological stress granules and Tau aggregates in Alzheimer ...