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16 天
NR0B1:食管癌鳞状细胞癌恶性表型调控关键基因及预后评估新指标
敲低 NR0B1 会使细胞周期调节因子 p21 和 p27 上调,同时胸苷激酶 1(TK1)、细胞周期蛋白 E1(cyclin E1)、细胞周期蛋白依赖性激酶 2(CDK2)和染色质许可和 DNA 复制因子 1(CDT1)下调,且这一过程不依赖于 p53。虽然组织中 NR0B1 表达升高与 TNM 分期没有显著关联 ...
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