CDK1/Cyclin B interacts with Aurora kinase A to enhance its phosphorylation and activation of PLK1. Aurora kinase A activity is inhibited by BRCA1. PLK1 induces CDC25C activation and WEE1 degradation ...

流式细胞术分析发现，Bf-B 处理后，PANC-1 和 BXPC-3 细胞在 S 期的比例显著增加。qPCR 和 Western blot 结果显示，Bf-B 能降低细胞周期检查点激酶 ATR、CHK1、CDC25C 及细胞周期蛋白 B1（Cyclin B1）/ 细胞周期蛋白依赖性激酶 1（CDK1）的表达，影响细胞周期进程。 诱导细胞 ...

The above conclusions combined clarify the role of plk1 in mitotic entry. Plk1 inhibition slows the accumulation of active cdc25C that in turn slows the onset of the positive feedback responsible for ...

Background: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been considered as a key promoting factor in atherosclerosis (AS). Some studies have shown that regulating EMMPRIN expression ...