糖尿病心脏自主神经病变(DCAN)是糖尿病常见且严重的并发症。来自国内的研究人员通过靶向P2Y12受体，探究了颈上神经节(SCG)中驻留巨噬细胞与卫星胶质细胞(SGCs)的相互作用机制。研究发现，DCAN大鼠SCG中P2Y12受体、胶质纤维酸性蛋白(GFAP)、巨噬细胞标志物(CSF1R/CSF1 ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

美国食品药品监督管理局批准了激酶抑制剂维姆塞替尼 (Romvimza，Deciphera Pharmaceuticals, LLC)，用于治疗手术切除可能会导致功能限制恶化或严重发病的有症状腱鞘巨细胞瘤 (TGCT) 成年患者。

In terms of response, it met its primary end point in all 3 doses. 1 The ORR was 50% or higher [in all 3 groups]. The dose of ...

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide. Despite the success of ...

Pexidartinib – which will be marketed under the Turalio trade name in the US - is an oral drug that inhibits CSF1R, KIT and FLT3, three molecular targets that can be used to unlock immune ...

此外，针对 CSF1R 和 CXCR2 的联合抑制疗法可有效阻断促肿瘤性 PMN - MDSC 的招募，抑制肿瘤生长；阻断 TGFβ 信号通路可减少免疫抑制，增强抗肿瘤免疫反应。 消除特定的 CAF 亚型治疗癌症：多种以候选基因表达为特征的 CAF 亚群可促进肿瘤生长，因此，靶向特定 ...

Common genetic leukoencephalopathies discussed in detail include CSF1R, AARS2, cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and mitochondrial and metabolic ...

During a live event, Catherine J. Lee, MD, MS, discussed the efficacy and safety results of various trials of approved agents ...

Your patient presents with pain, swelling and impaired knee function. One rare diagnosis is non-malignant tenosynovial giant cell tumor (TGCT). How to distinguish from arthritis and how to treat are ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

It becomes the second FDA-approved drug for the disease after Daiichi Sankyo's Turalio (pexidartinib), a CSF1R, KIT, and FLT3 inhibitor that was cleared by the FDA in 2019 for TGCT associated with ...