以往用于区分 NK 细胞和 ILC1s 的传统标记物，如 Eomes、CD49b、CD200R 等，由于在不同细胞状态下表达不稳定，无法准确区分这两种细胞。因此，寻找一种可靠的标记物来精准划分 NK 细胞和 ILC1s，成为免疫学领域亟待解决的重要问题。 为了攻克这一难题，来自美国 ...

支气管哮喘（bronchial asthma，简称哮喘）是一种以嗜酸性粒细胞、肥大细胞反应为主的气道变应性炎症和气道反应性为特征的疾病。由于哮喘的发病机制复杂，病因与发病机理尚不明了，临床实验受伦理及方法限制，因此需要通过构建哮喘动物模型来研究疾病发生 ...

Background: Lung inflammation, neutrophil infiltration, and pulmonary vascular leakage are pathological hallmarks of acute respiratory distress syndrome (ARDS) which can lethally complicate ...

The immune system provides host protection against pathogenic microorganisms as well as anti-tumor immunity. Importantly, regulatory mechanisms prevent immune reactivity against self- and harmless ...

This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC class I allele, can lead to NK cell licensing, thereby providing ...

人类NK细胞的常见表面标志物为CD56和CD16，而小鼠NK细胞则表达NK1.1和CD49b（DX5）。需要注意的是，T细胞亚群中的NKT细胞与NK细胞在表型和功能上有相似之处，NKT细胞同时表达CD16、CD56、NK1.1、CD49b，并能产生颗粒酶。因此，在进行NK细胞分型时，通常需要通过CD3阴性 ...

School of Biomolecular and Biomedical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland ...

4 Institute of Legal Medicine and Core Facility Metabolomics, Medical University Innsbruck, Innsbruck, Austria Objective Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell ...