Therefore, sepsis-induced changes in the MAIT cell compartment seem to be reversible by nature. Evolutionary conservation of CD1d and MR1 recognition across mammalian species makes animal models of ...

本研究揭示了HSV-1 UL56基因通过降解CD1d蛋白抑制NKT细胞功能的分子机制，为抗HSV-1感染研究提供了新靶点。 研究背景 单纯疱疹病毒（HSV-1）是一种具有强大免疫逃逸能力的病原体，其感染可引起多种疾病。CD1d限制性自然杀伤T（NKT）细胞在抗HSV-1免疫中发挥重要 ...

而NKT细胞扩增就复杂的多，本身NKT细胞占外周血T细胞不到1%，比例极低，需要CD1d+APC和α-GalCer刺激才能扩增。扩增效率远低于NK细胞，一般来说都不到10倍。

The Seagen cash injection comes on top of an $83 million round in 2020, which has helped Utrecht-based Lava bring its lead Gammabody LAVA-051 targeting CD1d into the clinic for haematological ...

In human beings, as well as in most non-human primates, the major peripheral γδ T cell subset, which accounts several percent of the whole lymphoid cells pool in adults, carries an heterodimeric TCR ...

这些细胞表面既有T细胞受体，又有NK细胞受体，能够特异性地被表面有CD1d分子的抗原提呈细胞激活，从而迅速释放大量的细胞因子。 iNKT细胞疗法通过利用这些细胞的功能，激活并增强机体的抗肿瘤免疫功能，对多种肿瘤，如肺癌、乳腺癌、大肠癌、肝癌 ...

Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and increased predisposition to acute myeloid leukemia. The causes of ...

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Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The globo-series glycosphingolipids (GSLs) are unique glycolipids exclusively ...

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