Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...

Updated results from BP1001-A obesity and Type 2 diabetes testing from the second stage of pre-clinical testing are as follows: Previously, Bio-Path reported BP1001-A increased insulin sensitivity in ...

6 - NBDG是一种荧光标记的脱氧葡萄糖类似物，用于体外研究细胞对葡萄糖的摄取过程。 由西安强化生物科技开发，其结构特点为葡萄糖分子6号位羟基被硝基苯并噁二唑（NBD）荧光基团取代，可模拟天然葡萄糖的跨膜转运，但后续代谢途径被阻断，从而在细胞内 ...

为解决弗里德赖希共济失调（FRDA）因线粒体蛋白 frataxin（FXN）缺乏导致的疾病问题，研究人员开展了关于融合蛋白 Nomlabofusp 的研究。结果显示 Nomlabofusp 能进入细胞并定位于线粒体，释放成熟且有生物活性的 FXN。这为 FRDA 治疗提供了新方向。 弗里德赖希共济 ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Could a natural fungus compound fight fatigue and sharpen your mind? New research suggests cordycepin might hold the key to boosting endurance and protecting brain function when pushed to the limit.

本文聚焦细胞外基质（ECM），研究发现 Matrix 经基质金属蛋白酶（MMPs）降解后，应力松弛增强，影响细胞黏附与铺展。通过调控基质降解性可调节应力松弛，为生物材料设计提供关键参数，对再生医学等意义重大。 细胞外基质（ECM）是蛋白质的复杂组合，赋予 ...

(A) The infection of Ad-Shh in MSCs (fluorescence microscope, × 100). (B) Validation of the expression of Shh by Ad-Shh in MSCs (Western blot). (C, D) The effects of Shh on BMP9-induced ALP ...

脂质纳米颗粒（ LNPs）作为一种先进的核酸药物递送系统，其性能优化尤为关键。尽管脂质组分研究已较成熟，但制备过程中 ...

This revised study provides valuable information on the single nucleus RNA sequencing transcriptome, pathways, and cell types in pig skeletal muscle in response to conjugated linoleic acid (CLA) ...