The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the APC. These are ...

3 ER stress and Unfolded Protein Response (UPR) i. IRE1α: When activated by unfolded proteins (indirectly via BiP, as discussed below), IRE1α splices XBP1 mRNA, which then encodes a transcription ...

在细胞的微观世界里，有一种名为 BiP（免疫球蛋白结合蛋白，immunoglobulin binding protein，也称为 78 kDa 葡萄糖调节蛋白，glucose-regulated protein 78，GRP78）的分子伴侣，主要居住在内质网（endoplasmic reticulum，ER）中，它在蛋白质的合成、折叠、组装以及跨内质网转运等 ...

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Independently, PERK inhibition can induce ER stress in β-cells, (2) PERK inhibition (by PERKi) prevents eIF2α phosphorylation, negatively impacting the UPR primarily through dysregulation of protein ...

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诱导过度的内质网应激（ER stress）是一种具有潜力的癌症治疗策略。然而，目前内质网应激激活剂在临床应用方面仍存在局限。在本研究中，研究人员通过体外 BiP ATP 酶活性测定，鉴定出一种从未被揭示的、从软毛地胆草中分离出的倍半萜内酯 EM-12，它是一种 BiP ...