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揭秘 APC15在小鼠卵母细胞减数分裂进程中的关键作用与奥秘
通过小干扰 RNA(siRNA)敲低 APC 15 ,虽然不会影响纺锤体的组织,但会导致减数分裂停滞在第一次减数分裂中期(MI),并损害 BUB3 从着丝粒上的去除,这表明纺锤体组装检查点(SAC)的失活受到了干扰。研究结果突出了 APC 15 参与卵母细胞中 SAC 的调控以及从中 ...
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