During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

1 Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China 2 Huaian Maternity and Child Healthcare Hospital of JiangSu ...

在肝癌中，低氧条件下 HIF-1α 诱导 YTHDF1 表达，YTHDF1 通过促进自噬相关基因 ATG2A 和 ATG14 的翻译，驱动缺氧诱导的自噬和癌细胞的恶性进展。然而，YTHDF1 在低氧条件下的调节较为复杂，在高原牛的肾脏和肝脏中，其水平相较于低地牛有所降低，表明其在低氧环境 ...