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As a crucial cellular process involved in degrading and recycling damaged organelles and proteins, autophagy-related (ATG) proteins mediated autophagy plays a significant role in various physiological ...

在营养缺乏的情况下，ULK1 会发生去磷酸化，导致复合物与 mTORC1 复合物分离。这种激活会导致 beclin-1/Vps34 复合物 (beclin-1-Atg14L-Vps15-Vps34) 的刺激，进而产生磷脂酰肌醇-3-磷酸。磷脂酰肌醇-3-磷酸的产生会触发双膜囊泡的成核，这一过程由成核位点的 DFCP1 和 WIPI ...

Cardiovascular diseases are one of the leading causes of death and global health problems worldwide. Multiple factors are known to affect the cardiovascular system from lifestyles, genes, underlying ...