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Antigen processing and presentation is the ... trafficking of the components of the ER dislocon complex to an endosomal or phagosomal compartment. The evidence that the ER dislocon complex ...

with different mechanisms being proposed for how Mtb antigens can access the cytosol. Recently, electron microscopy was used to demonstrate that Mtb has the potential to escape the phagosome and ...

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria ...

They protect nucleic acids, facilitate cellular uptake, and enable endosomal escape, allowing the nucleic acids to be delivered inside cells. The chemical structure of each component within the lipid ...

If LNPs can't escape, it's like a shuttle getting stuck in the docking process, the safety of the station just out of reach. "If the endosomal escape ... Padilla, who has a Ph.D. in Chemistry ...

After endosomal escape, AAVs can also successfully transduce the cell and deliver their viral ... Sensing of AAV vector components in plasmacytoid DCs (pDCs) by the innate immune system leads to the ...

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