本文聚焦肝细胞癌（HCC），发现 ACVR2A 失活通过激活 SMAD 信号通路，促进癌细胞糖酵解产乳酸，招募调节性 T 细胞（Treg），导致免疫逃逸和免疫治疗耐药。抑制 MCT4 可改善这一情况，为 HCC 免疫治疗提供新思路。 研究背景 肝细胞癌（HCC）是原发性肝癌的主要类型 ...

Pioneering AI technology successfully designs antibodies de novo for six therapeutic targets, including one without an experimentally resolved structure SEOUL, South Korea, March 17, 2025 /PRNewswire/ ...

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last four decades, there have ...

1 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States 2 Department of Urology, Beth Israel Deaconess Medical Center and Harvard Medical ...

Pioneering AI technology successfully designs antibodies de novo for six therapeutic targets, including one without an experimentally resolved structure SEOUL, South Korea, March 17, 2025 ...

Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors Chondrosarcomas are rare cancers of cartilage with limited systemic therapy options. To ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...