Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

which triggers excessive RHOA/ROCK signaling and actin polymerization, leading to melanocyte rounding and failure in melanosome transfer to keratinocytes.

Surprisingly, endothelial cells (ECs) can still invade if actin polymerization is inhibited. In this study, we show that endothelial tip cells employ an alternative mechanism of cell migration that is ...

They further propose that water influx increases hydrostatic pressure within the cells which may facilitate actin polymerization and formation membrane protrusions. In the revised version of the ...

Aim: The action of immune checkpoint inhibition (ICI) largely depends on antibody-dependent cellular phagocytosis (ADCP). We thus aim to develop ADCP-based ccRCC risk stratification as both prognostic ...

SCs and OECs also respond to and phagocytose bacteria, a function likely critical for tackling microbial invasion of the CNS via peripheral nerves. However, phagocytosis is not always effective; ...

Post-polymerization modification of incorporated monomer units focus on two types of reaction. One is the removal of protecting groups where monomers with the desired functionality are incompatible ...

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Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Fluorescent probes for cell plasma membranes (PM) generally exploit a noncovalent ...

This month's cover highlights the article Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies by Emma Partiot, Barbara Gorda, Raphael Gaudin and ...

Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States Wallace H. Coulter Department of ...